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Regenerative Medicine

Regenerative medicine is a field that focuses on replacing, repairing, or creating new tissues in the body. Goals for our companion animals are to reduce pain, help regenerate injured tissue, and return a joint, muscle, or tendon to its normal function. The most common techniques used in clinical medicine for pets are platelet-rich plasma and stem cell therapy. There is a lot of research in progress with regenerative medicine, especially in human medicine, so recommendations and indications will change as we learn more.

Platelet-Rich Plasma (PRP)
Our orthopedic patients’ most common PRP indications include chronic, non-healing injuries to muscle, tendon, and bone, as well as osteoarthritis.

The principle is to accelerate lagging internal healing processes by amplifying the biological signals that would naturally occur when platelets aggregate at a site of injury. By concentrating platelets and releasing more of those growth factors than would naturally occur – the intended effect is to attract stem cells and stimulate local tissue repair processes.

Platelet-rich plasma (PRP) therapy is performed by obtaining a blood sample from the patient. The patient’s blood is then processed to remove the red and white blood cells, leaving a solution containing concentrated platelets and plasma (the fluid potion of the blood). This process takes approximately 15 minutes.

Once the PRP is collected and processed, the regions of injury or osteoarthritis are injected with PRP. In many cases, sedation is required to facilitate the injection.

The side effects of PRP therapy are minimal and infrequent. Since the body’s own cells are being processed and injected using a sterile technique, allergic or infectious side effects are rare. In most situations, side effects are limited to discomfort and occasional bruising at the injection site.

The most common problems that we treat (or supplement) with PRP include:

Osteoarthritis (hip, elbow, stifle, tarsus, carpus or shoulder)
Medial shoulder instability
Biceps tendinopathy
Supraspinatus tendinopathy
Achilles (calcaneal) tendon injury

Each indication of PRP therapy may have a different protocol for injections. In most situations, the outcome is optimized using multiple injections, and we typically administer three injections at 3-week intervals.

The benefit of PRP therapy has been documented with small studies of dogs with certain conditions, but the literature is sparse on the actual effectiveness in all situations. Most of our recommendations are based on our experience and the experience of others who utilize regenerative therapies frequently.

Stem Cell Therapy
Stem cells are responsible for creating all the different tissues in the body as a fetus, and continue to maintain those tissues through adulthood. There are three main types of stem cells: embryonic stem cells, adult stem cells, and fetal stem cells. As an adult, our stem cells are found throughout the body, and help in the healing process.

Mesenchymal stem cells (MSC) are most commonly isolated from adult bone marrow or fat, and do not retain the ability to form all types of tissue in the body like embryonic stem cells. However, MSC can divide quickly and become bone, cartilage, or tendon, making MSCs an excellent choice for orthopedic medicine. Stem cell therapy involves the isolation of adult stem cells and the administration of these cells into areas of injury and chronic inflammation (e.g. joints, soft tissues, and organs). After administration, the stem cells can grow and proliferate. They produce substances that help to promote healing and modulate inflammation.

Indications
The predominant application for regenerative stem cell therapy is for the alleviation of pain secondary to osteoarthritis in dogs and cats.
Other reported uses include: inflammatory bowel disease, chronic hepatitis or chronic pancreatitis, tendon and ligament injury, immune-mediated polyarthritis
Patients are good candidates for stem cell therapy if medical treatment (such as nonsteroidal anti-inflammatories) or orthopedic surgery are not viable options due to concurrent illnesses. Cancer, infection, and steroid therapy are all contraindications to stem cell therapy. While harvesting of MSC requires general anesthesia and a small incision, it is a rapid procedure and most patients will be discharged the same day.

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